TOTAL SYNTHESES OF BELLENAMINE AND ITS ISOMERS
1992 年 45 巻 10 号 p. 1677-1680
詳細
1992 年 45 巻 10 号 p. 1677-1680
The total synthesis of bellenamine was achieved by a modified CURTIUS procedure starting with D-β-lysine. Bis(N-benzyloxycarbonyl)-D-β-lysylglycine was converted to tris(N-benzyloxycarbonyl)bellenamine which was catalytically hydrogenated to yield bellenamine. D-β-Lysine was synthesized from D-ornithine by the ARNDT-EISTERT homologation sequence. Three isomers, L-β-lysyl, D- and L-lysyl congeners synthesized by a similar method, showed no antibacterial activities.
