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I. TAXONOMY, ISOLATION, AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
MAYUMI ITO, MASAFUMI MARUHASHI, NORIYOSHI SAKAI, KAZUTOSHI MIZOUE, KAZ ...
1992 年 45 巻 10 号 p.
1559-1565
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
NG-011 and NG-012, novel potentiators of nerve growth factor (NGF), were isolated from the culture broth of
Penicillium verruculosum F-4542, together with 3, 4-dihydro-6, 8-dihydroxy-3-methylisocoumarin. They potentiated the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12).
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II. THE STRUCTURE DETERMINATION OF NG-011 AND NG-012
MAYUMI ITO, YUKIKO TSUCHIDA, KAZUTOSHI MIZOUE, KAZUNORI HANADA
1992 年 45 巻 10 号 p.
1566-1572
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
NG-011 and NG-012, novel potentiators of nerve growth factor (NGF) were isolated from the culture broth of
Penicillium verruculosum F-4542.
The structures of NG-011 and NG-012 were elucidated by their spectral analysis and degradation experiments as shown in Fig. 1.
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I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITIES
SOICHIRO TODA, YUMIKO OBI, KEI-ICHI NUMATA, YASUTARO HAMAGISHI, KOJI T ...
1992 年 45 巻 10 号 p.
1573-1579
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
Eurystatins A and B, were isolated from the cultured broth of
Streptomyces eurythermus R353-21. They showed specific and potent inhibitory activity against prolyl endopeptidase and did not show antimicrobial activity. No lethal toxicity was observed for the two compounds after ip administration in mice at 200 mg/kg.
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II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION
SOICHIRO TODA, CHIKAKO KOTAKE, TAKASHI TSUNO, YUKIO NARITA, TETSURO YA ...
1992 年 45 巻 10 号 p.
1580-1586
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
The structures of eurystatins A and B, new prolyl endopeptidase inhibitors, have been elucidated by chemical degradation and spectral studies. They have in common a unique 13-membered cyclic peptide core composed of L-leucine, L-ornithine and (
S)-3-amino-2-oxobutyric acid, and differ from each other in the α, β-unsaturated fatty acid attached to the α-amino moiety of the ornithine.
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TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES
TAKAAKI AOYAGI, TAKAYUKI AOYAMA, FUKIKO KOJIMA, SEIKO HATTORI, YOSHIKO ...
1992 年 45 巻 10 号 p.
1587-1591
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
Cyclooctatin has been isolated from
Streptomyces melanosporofaciens MI614-43F2 as part of a program designed to find microorganism-produced inhibitors of lysophospholipase. It was purified by chromatography on silica gel, Capcell Pak C
18 (HPLC) and Sephadex LH-20 followed by solvent extraction and then isolated as a colorless powder. Cyclooctatin has the molecular formula of C
20H
34O
3. It is competitive with the substrate, and the inhibition constant (
Ki) was 4.8×10
-6M.
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KIRITY ROY, E. K. S. VIJAYAKUMAR, TRIPTIKUMAR MUKHOPADHYAY, SUGATA CHA ...
1992 年 45 巻 10 号 p.
1592-1598
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
Two new secondary metabolites, aranorosinol A (
1) and aranorosinol B (
2), were isolated from a strain of
Pseudoarachniotus roseus. Their structures were elucidated on the basis of their spectral properties and chemical transformations and were found to be similar to aranorosin (
3) isolated from the same strain.
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MITSUNORI NAKATA, MOTOAKI SAITO, YOSHIO INOUYE, SHOSHIRO NAKAMURA, YOI ...
1992 年 45 巻 10 号 p.
1599-1608
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
A novel anthracycline antibiotic, cinerubin R, was isolated from the fermentation broth of
Streptomyces eurythermus strain H1715MY2. The structure of cinerubin R was elucidated to be 4"-aculosyl-4"-rhodinosyl-7-rhodosaminyl-ε-pyrromycinone. Cinerubin R was active against Gram-positive bacteria and inhibited the growth of divergent multi-drug-resistant cells to the same extent as their parental cells.
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AKIHIRO YOSHIMOTO, OSAMU JOHDO, HIROSHI TONE, ROKUROU OKAMOTO, HIROSHI ...
1992 年 45 巻 10 号 p.
1609-1617
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
A limited biosynthetic conversion of some known anthracyclinones using a specific daunorubicin-nonproducing mutant provided four new anthracycline antibiotics: 1-Hydroxy-10-methoxycarbonyl-13-deoxocarminomycin; 1-hydroxy-13-deoxocarminomycin; 1-hydroxyoxaunomycin and 6-deoxyoxaunomycin. Their isolation and purification from bioconversion broth, structural determination and antitumor activities against leukemic L1210 cells are described.
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TAKAO KATAOKA, JUNJI MAGAE, KUNIHIRO KASAMO, HIROYASU YAMANISHI, AKIRA ...
1992 年 45 巻 10 号 p.
1618-1625
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
Prodigiosin 25-C inhibited the proliferation of various cultured cell lines more strongly when concanavalin A (Con A) was added to the cultures. The increase in sensitivity was most evident in T lymphoma YAC-1 cells. The combination of prodigiosin 25-C and Con A induced characteristic morphological changes in these cells. In the presence of Con A, monovalent polyether ionophores and vacuolar type H
+-ATPase inhibitors induced effects similar to those of prodigiosin 25-C on YAC-1 cells. Prodigiosin 25-C had neither K
+ionophore activity nor inhibitory effect on vacuolar type H
+-ATPase. A Golgi mannosidase II inhibitor, swainsonine, inhibited the proliferation of YAC-1 cells only when Con A was added. Prodigiosin 25-C and swainsonine increased Con A binding receptors on the surface of YAC-1 cells. These results suggest that prodigiosin 25-C affects the intracellular transport and/or processing of glycoproteins.
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HIROSHI TOMODA, XIN-HUI HUANG, JIN CAOA, HIROYUKI NISHIDA, RYUICHI NAG ...
1992 年 45 巻 10 号 p.
1626-1632
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
The effect was studied of the fungal cyclodepsipeptide antibiotics beauvericin and seven distinct enniatins on acyl-CoA: cholesterol acyltransferase (ACAT) activity. In an enzyme assay using rat liver microsomes, all the compounds were found to inhibit ACAT activity. The drug concentration that caused 50% inhibition (IC
50 value) of the enzyme activity was determined to be 3.0μM for beauvericin, indicating that the compound is one of the most potent ACAT inhibitors of microbial origin. Enniatins exhibited much higher IC
50 values of 22 to 110μM. More hydrophobic enniatins showed more potent inhibitory activity. Furthermore, the ACAT inhibitory activity was evaluated as inhibition of cholesteryl ester formation in a cell assay using J774 macrophages. Calculation of the ratio, CD
50 value (the drug concentration causing 50% cell damage)/IC
50 value of cholesteryl ester formation, indicated that beauvericin shows the highest specificity. These data indicate that beauvericin is one of the most potent and specific ACAT inhibitors of microbial origin.
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PIERFAUSTO SENECI, ALDO TRANI, PIETRO FERRARI, ROBERTO SCOTTI, ROMEO C ...
1992 年 45 巻 10 号 p.
1633-1644
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
A series of O56-substituted carboxyester or carboxyamide derivatives of deglucoteicoplanin (TD) was prepared by condensation of the 56-hydroxyl function with various alkylating agents of general formula RBr, where R represents functional groups with different physico-chemical properties.
The modifications at position 56 influenced the antimicrobial activity of the new derivatives; activity depended on the structure of various R groups, their ionic properties, and their steric hindrance.
The activity of the new compounds did not show any significant improvement when compared with TD.
The physico-chemical and antibacterial properties of the synthesized compounds are reported.
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DAISHIRO IKEDA, TOSHIO NISHIZUKA, SHYH-PYNG HUANG, SHINICHI KONDO, TOM ...
1992 年 45 巻 10 号 p.
1645-1652
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
Desalaninebenanomicin A has been synthesized in good yield by the cleavage of the amido bond of benanomicin A using MEERWEIN'S reagent. This is a useful intermediate to prepare amino acid analogs of benanomicin A. MEERWEIN'S reagent reacts with totally protected benanomicin A to give a stable imino ether. After deprotection, the imino ether is treated with aqueous acetone at reflux to afford a methyl ester of desalaninebenanomicin A. Desalaninebenanomicin A was coupled with a variety of amino acids by the active ester method to afford new benanomicin analogs.
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OSAMU JOHDO, HIROSHI TONE, ROKURO OKAMOTO, AKIHIRO YOSHIMOTO, HIROSHI ...
1992 年 45 巻 10 号 p.
1653-1661
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
New
N-monodemethyl and
N-didemethyl derivatives were obtained from seven
N-dimethylamino sugar (rhodosamine)-containing anthracyclines by photochemical reaction and their
in vitro bioactivities against LI210 cell culture were compared with those of their
N-dimethyl parent compounds.
N-Demethyl derivatives obtained from betaclamycin T (7-
O-rhodosaminyl-β-rhodomycinone) were much more cytotoxic while those from the other six antibiotics were rather less active as compared with their parent compounds. The
N-demethylation also gave a considerably greater decrease in the inhibitory activity on RNA synthesis as compared to DNA synthesis, so that the
N-demethyl derivatives showed smaller IC
50 ratios on DNA/RNA than their parent compounds.
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TOSHIAKI KUDO, YOSHIO NISHIMURA, SHINICHI KONDO, TOMIO TAKEUCHI
1992 年 45 巻 10 号 p.
1662-1668
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
N-Substituted derivatives of siastatin
B have been obtained by a chemical modification. Some derivatives showed potent inhibitory activities against
Streptococcus sp. and
Clostridium perfringens neuraminidases.
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II. STRUCTURE ELUCIDATION OF GLISOPRENINS A AND B
HIROYUKI NISHIDA, XIN-HUI HUANG, HIROSHI TOMODA, SATOSHI OMURA
1992 年 45 巻 10 号 p.
1669-1676
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
The structure of glisoprenins A and B, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses, mainly
1H and
13C NMR and MS. Glisoprenin A was deduced to be a tetrahydroxynonaprenol and glisoprenin B to be an oxidative modification of glisoprenin A.
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YOKO IKEDA, DAISHIRO IKEDA, SHINICHI KONDO
1992 年 45 巻 10 号 p.
1677-1680
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
The total synthesis of bellenamine was achieved by a modified CURTIUS procedure starting with D-β-lysine. Bis(
N-benzyloxycarbonyl)-D-β-lysylglycine was converted to tris(
N-benzyloxycarbonyl)bellenamine which was catalytically hydrogenated to yield bellenamine. D-β-Lysine was synthesized from D-ornithine by the ARNDT-EISTERT homologation sequence. Three isomers, L-β-lysyl, D- and L-lysyl congeners synthesized by a similar method, showed no antibacterial activities.
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DAISUKE KOMAGATA, RYUICHI SAWA, NAOKO KINOSHITA, CHIAKI IMADA, TSUTOMU ...
1992 年 45 巻 10 号 p.
1681-1683
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
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HIROSHI OHASHI, HIROKAZU AKIYAMA, KOJI NISHIKORI, JUN-ICHIRO MOCHIZUKI
1992 年 45 巻 10 号 p.
1684-1685
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
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SHINJI FUNAYAMA, SHIGEO NOZOE, CLAUDE TRONQUET, YUMI ANRAKU, KANKI KOM ...
1992 年 45 巻 10 号 p.
1686-1691
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
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WENDY S. HORN, JACK L. SMITH, GERALD F. BILLS, SUSAN L. RAGHOOBAR, GRE ...
1992 年 45 巻 10 号 p.
1692-1696
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
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CLIFFORD C. HALL, ANNE BERTASSO, JOHN D. WATKINS, NAFSIKA H. GEORGOPAP ...
1992 年 45 巻 10 号 p.
1697-1699
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
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KENJI KANBE, HIROSHI NAGANAWA, YOSHIRO OKAMI, TOMIO TAKEUCHI
1992 年 45 巻 10 号 p.
1700-1702
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
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TAKAYUKI AOYAMA, HIROSHI NAGANAWA, YASUHIKO MURAOKA, TAKAAKI AOYAGI, T ...
1992 年 45 巻 10 号 p.
1703-1704
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー
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BURTON H. JAYNES, NANCY C. ELLIOTT, DOUGLAS L. SCHICHO
1992 年 45 巻 10 号 p.
1705-1707
発行日: 1992/10/25
公開日: 2006/04/19
ジャーナル
フリー