COCHINMICINS, NOVEL AND POTENT CYCLODEPSIPEPTIDE ENDOTHELIN ANTAGONISTS FROM A Microbispora sp. I. PRODUCTION, ISOLATION, AND CHARACTERIZATION

Y. K. TONY LAM; DAVID L. WILLIAMS; JANET M. SIGMUND; MANUEL SANCHEZ; OLGA GENILLOUD; YU L. KONG; SIOBHAN STEVENS-MILES; LEEYUAN HUANG; GEORGE M. GARRITY

doi:10.7164/antibiotics.45.1709

COCHINMICINS, NOVEL AND POTENT CYCLODEPSIPEPTIDE ENDOTHELIN ANTAGONISTS FROM A Microbispora sp.

I. PRODUCTION, ISOLATION, AND CHARACTERIZATION

Y. K. TONY LAM, DAVID L. WILLIAMS, JANET M. SIGMUND, MANUEL SANCHEZ, OLGA GENILLOUD, YU L. KONG, SIOBHAN STEVENS-MILES, LEEYUAN HUANG, GEORGE M. GARRITY

著者情報

ジャーナルフリー

1992 年 45 巻 11 号 p. 1709-1716

DOI https://doi.org/10.7164/antibiotics.45.1709

詳細

抄録

Cochinmicins I, II, III are novel peptolides produced in submerged-fermentation cultures of Microbispora sp. ATCC 55140. These closely related compounds are separated by HPLC and are novel competitive endothelin antagonists. Cochinmicins II and III are stereoisomeric to each other. Cochinmicin I is the deschloro analog of cochinmicin III.

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