EPOXOMICIN, A NEW ANTITUMOR AGENT OF MICROBIAL ORIGIN

MINORU HANADA; KOKO SUGAWARA; KEIKO KANETA; SOICHIRO TODA; YUJI NISHIYAMA; KOJI TOMITA; HARUAKI YAMAMOTO; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.45.1746

MINORU HANADA, KOKO SUGAWARA, KEIKO KANETA, SOICHIRO TODA, YUJI NISHIYAMA, KOJI TOMITA, HARUAKI YAMAMOTO, MASATAKA KONISHI, TOSHIKAZU OKI

著者情報

ジャーナルフリー

1992 年 45 巻 11 号 p. 1746-1752

DOI https://doi.org/10.7164/antibiotics.45.1746

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抄録

An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16 melanoma. Structural studies indicated that it is a new member of the epoxy-β-aminoketone group, and is closely related to eponemycin.

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