A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR ACTIVITY I. TAXONOMY AND FERMENTATION OF THE PRODUCING STRAIN, ISOLATION AND CHARACTERIZATION OF SF2575

MASAHIRO HATSU; TORU SASAKI; HIRO-OMI WATABE; SHINJI MIYADOH; MIEKO NAGASAWA; TAKASHI SHOMURA; MASAJI SEZAKI; SHIGEHARU INOUYE; SHINICHI KONDO

doi:10.7164/antibiotics.45.320

A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR ACTIVITY

I. TAXONOMY AND FERMENTATION OF THE PRODUCING STRAIN, ISOLATION AND CHARACTERIZATION OF SF2575

MASAHIRO HATSU, TORU SASAKI, HIRO-OMI WATABE, SHINJI MIYADOH, MIEKO NAGASAWA, TAKASHI SHOMURA, MASAJI SEZAKI, SHIGEHARU INOUYE, SHINICHI KONDO

著者情報

MASAHIRO HATSU
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
TORU SASAKI
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
HIRO-OMI WATABE
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
SHINJI MIYADOH
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
MIEKO NAGASAWA
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
TAKASHI SHOMURA
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
MASAJI SEZAKI
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
SHIGEHARU INOUYE
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
SHINICHI KONDO
Institute of Microbial Chemistry

ジャーナルフリー

1992 年 45 巻 3 号 p. 320-324

DOI https://doi.org/10.7164/antibiotics.45.320

詳細

抄録

A new antitumor antibiotic SF2575 has been isolated from a culture filtrate of Streptomyces sp. SF2575. The molecular formula was determined to be C₄₀H₄₃NO₁₅ by elemental analysis, mass and ¹³C NMR spectral analyses. The spectral data revealed SF2575 to be a new tetracycline antibiotic. It was active against Gram-positive bacteria and exhibited antitumor activity against P388 leukemia in mice.

責任著者(Corresponding author)

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