A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR ACTIVITY II. THE STRUCTURAL ELUCIDATION OF SF2575

MASAHIRO HATSU; TORU SASAKI; SHUICHI GOMI; YOSHIO KODAMA; MASAJI SEZAKI; SHIGEHARU INOUYE; SHINICHI KONDO

doi:10.7164/antibiotics.45.325

A NEW TETRACYCLINE ANTIBIOTIC WITH ANTITUMOR ACTIVITY

II. THE STRUCTURAL ELUCIDATION OF SF2575

MASAHIRO HATSU, TORU SASAKI, SHUICHI GOMI, YOSHIO KODAMA, MASAJI SEZAKI, SHIGEHARU INOUYE, SHINICHI KONDO

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ジャーナルフリー

1992 年 45 巻 3 号 p. 325-330

DOI https://doi.org/10.7164/antibiotics.45.325

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抄録

The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton which is structurally related to the tetracycline antibiotics and it is unique by bearing C-glycoside, salicylic acid and angelic acid moieties.

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