KS-505a, A NOVEL INHIBITOR OF BOVINE BRAIN Ca2+ AND CALMODULIN-DEPENDENTCYCLIC-NUCLEOTIDE PHOSPHODIESTERASE FROM Streptomyces argenteolus
1992 年 45 巻 3 号 p. 341-347
詳細
1992 年 45 巻 3 号 p. 341-347
A novel compound, KS-505a was isolated from the culture broth of a strain identified as Streptomyces argenteolus A-2. The compound inhibited bovine brain Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase with an IC50 value (the concentration causing 50% inhibition) of 0.065μM. The compound around that concentration had little or no effect on heart calmodulin-dependent and -independent cyclic-nucleotide phosphodiesterases, and protein kinase C.
