A NEW ANGIOGENESIS INHIBITOR, FR-111142

TAKANAO OTSUKA; TOSHIHIRO SHIBATA; YASUHISA TSURUMI; SHIGEHIRO TAKASE; MASAKUNI OKUHARA; HIROSHI TERANO; MASANOBU KOHSAKA; HIROSHI IMANAKA

doi:10.7164/antibiotics.45.348

TAKANAO OTSUKA, TOSHIHIRO SHIBATA, YASUHISA TSURUMI, SHIGEHIRO TAKASE, MASAKUNI OKUHARA, HIROSHI TERANO, MASANOBU KOHSAKA, HIROSHI IMANAKA

著者情報

ジャーナルフリー

1992 年 45 巻 3 号 p. 348-354

DOI https://doi.org/10.7164/antibiotics.45.348

詳細

抄録

FR-111142 is a new angiogenesis inhibitor produced by a fungus Scolecobasidium arenarium F-2015.
FR-111142 inhibited endothelial cell proliferation in vitro and angiogenesis in the growing chick chorioallantoic membrane model in vivo. Further, FR-111142 also suppressed the solid tumor growth in mice.

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