SYNTHESIS OF 7-O-[2, 6-DIDEOXY-2-FLUORO-4-O-(3-FLUOROTETRA-HYDROPYRAN-2-YL)-α-L-TALOPYRANOSYL]DAUNOMYCINONE
1992 年 45 巻 3 号 p. 355-362
詳細
1992 年 45 巻 3 号 p. 355-362
7-O-[2, 6-Dideoxy-2-fluoro-4-O-(3-fluorotetrahydropyran-2-yl)-α-L-talopyranosyl]daunomycinones (7a-7c) have been prepared by condensation of 3'-O-benzoyl derivative of 7-O-(2, 6-dideoxy-2-fluoro-α-L-talopyranosyl)daunomycinone with 2, 3-difluorotetrahydropyran as the key reaction. Antitumor activities of these compounds are described.
