ADENOPHOSTINS A AND B: POTENT AGONISTS OF INOSITOL-1, 4, 5-TRISPHOSPHATE RECEPTOR PRODUCED BY Penicillium brevicompactum TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

MASAAKI TAKAHASHI; TAKESHI KAGASAKI; TSUYOSHI HOSOYA; SHUJI TAKAHASHI

doi:10.7164/antibiotics.46.1643

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

ADENOPHOSTINS A AND B: POTENT AGONISTS OF INOSITOL-1, 4, 5-TRISPHOSPHATE RECEPTOR PRODUCED BY Penicillium brevicompactum

TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

MASAAKI TAKAHASHI, TAKESHI KAGASAKI, TSUYOSHI HOSOYA, SHUJI TAKAHASHI

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 11 Pages 1643-1647

DOI https://doi.org/10.7164/antibiotics.46.1643

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Abstract

New inositol-1, 4, 5-trisphosphate (InsP₃) agonists, adenophostins A(1) and B(2), were isolated from the culture broth of Penicillium brevicompactum SANK 11991 and SANK 12177. Its structures were related to adenine nucleotides. The agonistic activity of adenophostins A or B for binding to the InsP₃ receptor was higher than InsP₃ itself.

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