AQUASTATIN A, AN INHIBITOR OF MAMMALIAN ADENOSINE TRIPHOSPHATASES FROM Fusarium aquaeductuum TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES

KIYOSHI HAMANO; MASAKO KINOSHITA-OKAMI; KATSUHIRO MINAGAWA; HIDEYUKI HARUYAMA; TAKESHI KINOSHITA; TSUYOSHI HOSOYA; KOUHEI FURUYA; KAZUYA KINOSHITA; KEIICHI TABATA; ATSUKO HEMMI; KAZUHIKO TANZAWA

doi:10.7164/antibiotics.46.1648

AQUASTATIN A, AN INHIBITOR OF MAMMALIAN ADENOSINE TRIPHOSPHATASES FROM Fusarium aquaeductuum

TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES

KIYOSHI HAMANO, MASAKO KINOSHITA-OKAMI, KATSUHIRO MINAGAWA, HIDEYUKI HARUYAMA, TAKESHI KINOSHITA, TSUYOSHI HOSOYA, KOUHEI FURUYA, KAZUYA KINOSHITA, KEIICHI TABATA, ATSUKO HEMMI, KAZUHIKO TANZAWA

Author information

KIYOSHI HAMANO
Fermentation Research Laboratories, Sankyo Co., Ltd.
Present address: Biomedical Research Laboratories, Sankyo Co., Ltd.
MASAKO KINOSHITA-OKAMI
Fermentation Research Laboratories, Sankyo Co., Ltd.
KATSUHIRO MINAGAWA
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
HIDEYUKI HARUYAMA
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
TAKESHI KINOSHITA
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
TSUYOSHI HOSOYA
Tsukuba Research Laboratories, Sankyo Co., Ltd.
KOUHEI FURUYA
Tsukuba Research Laboratories, Sankyo Co., Ltd.
KAZUYA KINOSHITA
Biological Research Laboratories, Sankyo Co., Ltd.
KEIICHI TABATA
Biological Research Laboratories, Sankyo Co., Ltd.
ATSUKO HEMMI
Fermentation Research Laboratories, Sankyo Co., Ltd.
KAZUHIKO TANZAWA
Fermentation Research Laboratories, Sankyo Co., Ltd.

JOURNAL FREE ACCESS

1993 Volume 46 Issue 11 Pages 1648-1657

DOI https://doi.org/10.7164/antibiotics.46.1648

Details

Abstract

A new inhibitor of mammalian adenosine triphosphatases, designated aquastatin A, has been isolated from a fungus identified as Fusarium aquaeductuum. The structure of this compound has been determined by MS and NMR analyses. It inhibits Na⁺/K⁺-ATPase with an IC₅₀ value of 7.1 μM, and H⁺/K⁺-ATPase with an apparent IC₅₀ value of 6.2 μM.

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