DELAMINOMYCINS, NOVEL NONPEPTIDE EXTRACELLULAR MATRIX RECEPTOR ANTAGONIST AND A NEW CLASS OF POTENT IMMUNOMODULATOR

II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION OF DELAMINOMYCIN A

Abstract

Delaminomycins, novel extracellular matrix receptor antagonists, have been isolated from a culture broth of Streptomyces albulus MJ202-72F3. The structure of delaminomycin A was determined to be 3-[[2-[(3E, 5E)-2, 8-dihydroxy-7-methyl-3, 5-decadienyl]-1, 6, 8-trimethyl-1, 2, 4a, 5, 6, 7, 8, 8a-octahydrol-naphthyl]carbonyl]-5-hydroxypyrrolidine-2, 4-dione by analyses of spectral properties and chemical studies.