The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
CHEMICAL TRANSFORMATION OF GILVOCARCIN V
MODIFICATION OF THE SIDE-CHAIN
OSAMU KIKUCHI, TADASHI EGUCHI, KATSUMI KAKINUMA, YASUHIKO KOEZUKA, KAZUTOSHI SHINDO, NOBORU OTAKE
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JOURNAL FREE ACCESS

1993 Volume 46 Issue 6 Pages 985-991

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Abstract

Gilvocarcin V was chemically transformed to alter its biological activities as well as its solubility by mainly focusing on the vinyl side chain. The oxirane and oxime derivatives showed slightly decreased in vivo antitumor activity, while the aminoethylmorpholine derivative turned out to be soluble in some organic solvents.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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