PYRIPYROPENES, NOVEL INHIBITORS OF ACYL-CoA: CHOLESTEROL ACYLTRANSFERASE PRODUCED BY Aspergillus fumigatus I. PRODUCTION, ISOLATION, AND BIOLOGICAL PROPERTIES

HIROSHI TOMODA; YOUNG KOOK KIM; HIROYUKI NISHIDA; ROKURO MASUMA; SATOSHI OMURA

doi:10.7164/antibiotics.47.148

PYRIPYROPENES, NOVEL INHIBITORS OF ACYL-CoA: CHOLESTEROL ACYLTRANSFERASE PRODUCED BY Aspergillus fumigatus

I. PRODUCTION, ISOLATION, AND BIOLOGICAL PROPERTIES

HIROSHI TOMODA, YOUNG KOOK KIM, HIROYUKI NISHIDA, ROKURO MASUMA, SATOSHI OMURA

著者情報

ジャーナルフリー

1994 年 47 巻 2 号 p. 148-153

DOI https://doi.org/10.7164/antibiotics.47.148

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抄録

Aspergillus fumigatus FO-1289, a soil isolate, was found to produce a series of novel inhibitors of acyl-CoA: cholesterol acyltansferase (ACAT). Four active compounds, named pyripyropenes A, B, C and D, were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography, ODS column chromatography and preparative HPLC. Pyripyropenes A, B, C and D show very potent ACAT inhibitory activity in an enzyme assay system using rat liver microsomes with IC₅₀ values of 58, 117, 53 and 268 nM, respectively.

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