Bassiatin, a New Platelet Aggregation Inhibitor Produced by Beauveria bassiana K-717

TERUMI KAGAMIZONO; EMIKO NISHINO; KEITA MATSUMOTO; AKIRA KAWASHIMA; MARI KISHIMOTO; NORIYOSHI SAKAI; BI-MEI HE; ZENG-XIANG CHEN; TAKASHI ADACHI; SHIGEO MORIMOTO; KAZUNORI HANADA

doi:10.7164/antibiotics.48.1407

Bassiatin, a New Platelet Aggregation Inhibitor Produced by Beauveria bassiana K-717

TERUMI KAGAMIZONO, EMIKO NISHINO, KEITA MATSUMOTO, AKIRA KAWASHIMA, MARI KISHIMOTO, NORIYOSHI SAKAI, BI-MEI HE, ZENG-XIANG CHEN, TAKASHI ADACHI, SHIGEO MORIMOTO, KAZUNORI HANADA

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ジャーナルフリー

1995 年 48 巻 12 号 p. 1407-1413

DOI https://doi.org/10.7164/antibiotics.48.1407

詳細

抄録

A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1, 4-perhydrooxazine-2, 5-dione by NMR analysis, X-ray crystallographic analysis and chemical synthesis. Bassiatin inhibited ADP-induced aggregation of rabbit platelets with the IC₅₀ being 1.9×10^-4M.

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