The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
3'-Demethoxy-3'-hydroxystaurosporine, a Novel Staurosporine Analogue Produced by a Blocked Mutant
PASCALE HOEHNORESTE GHISALBATHEOPHILE MOERKERHEINRICH H. PETER
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JOURNAL FREE ACCESS

1995 Volume 48 Issue 4 Pages 300-305

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Abstract
3'-Demethoxy-3'-hydroxystaurosporine, 1 (CGP 58 546), a novel Staurosporine analogue, was isolated from a mutant of Streptomyces longisporoflavus R19 blocked in the last step of the biosynthetic pathway. CGP 58 546 was less potent than Staurosporine, but it showed a more selective inhibition pattern against various subtypes of protein kinase C.
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© Japan Antibiotics Research Association
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