Trachyspic Acid, a New Metabolite Produced by Talaromyces trachyspermus, that Inhibits Tumor Cell Heparanase: Taxonomy of the Producing Strain, Fermentation, Isolation, Structural Elucidation, and Biological Activity

HIDEYUKI SHIOZAWA; MASAAKI TAKAHASHI; TOSHIO TAKATSU; TAKESHI KINOSHITA; KAZUHIKO TANZAWA; TSUYOSHI HOSOYA; KOUHEI FURUYA; SHUJI TAKAHASHI; KAZUO FURIHATA; HARUO SETO

doi:10.7164/antibiotics.48.357

Trachyspic Acid, a New Metabolite Produced by Talaromyces trachyspermus, that Inhibits Tumor Cell Heparanase: Taxonomy of the Producing Strain, Fermentation, Isolation, Structural Elucidation, and Biological Activity

HIDEYUKI SHIOZAWA, MASAAKI TAKAHASHI, TOSHIO TAKATSU, TAKESHI KINOSHITA, KAZUHIKO TANZAWA, TSUYOSHI HOSOYA, KOUHEI FURUYA, SHUJI TAKAHASHI, KAZUO FURIHATA, HARUO SETO

著者情報

HIDEYUKI SHIOZAWA
Biomedical Research Laboratories, Sankyo Co., Ltd.
MASAAKI TAKAHASHI
Biological Research Laboratories, Sankyo Co., Ltd.
TOSHIO TAKATSU
Biomedical Research Laboratories, Sankyo Co., Ltd.
TAKESHI KINOSHITA
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
KAZUHIKO TANZAWA
Biological Research Laboratories, Sankyo Co., Ltd.
TSUYOSHI HOSOYA
Tsukuba Research Laboratories, Sankyo Co., Ltd.
KOUHEI FURUYA
Tsukuba Research Laboratories, Sankyo Co., Ltd.
SHUJI TAKAHASHI
Biomedical Research Laboratories, Sankyo Co., Ltd.
KAZUO FURIHATA
Division of Agriculture and Agricultural Life Sciences, The University of Tokyo
HARUO SETO
Institute of Molecular and Cellular Biosciences, The University of Tokyo

ジャーナルフリー

1995 年 48 巻 5 号 p. 357-362

DOI https://doi.org/10.7164/antibiotics.48.357

詳細

抄録

Trachyspic acid, a new metabolite that inhibited heparanase, was isolated from the culture broth of Talaromyces trachyspermus SANK 12191. Its structure was deduced from NMR spectral analyses and chemical reactions as a tricarboxylic acid derivative containing a spiroketal. The IC₅₀ value of trachyspic acid against heparanase was 36 μM.

責任著者(Corresponding author)

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