Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis I. Taxonomy, Fermentation, Isolation and Antimicrobial Activities

NAOKI MATSUMOTO; TOSHIO TSUCHIDA; MAYA UMEKITA; NAOKO KINOSHITA; HIRONOBU IINUMA; TSUTOMU SAWA; MASA HAMADA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.50.900

Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis

I. Taxonomy, Fermentation, Isolation and Antimicrobial Activities

NAOKI MATSUMOTO, TOSHIO TSUCHIDA, MAYA UMEKITA, NAOKO KINOSHITA, HIRONOBU IINUMA, TSUTOMU SAWA, MASA HAMADA, TOMIO TAKEUCHI

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 11 Pages 900-905

DOI https://doi.org/10.7164/antibiotics.50.900

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Abstract

A new structural class of the antibiotic, epoxyquinomicins A, B, C and D were isolated from the culture broth of the strain MK299-95F4, which was related to Amycolatopsis sulphurea. Antimicrobial activity of epoxyquinomicins A and B were weak against Gram-positive bacteria, and epoxyquinomicins C and D showed almost no antimicrobial activity and no cytotoxicity. All these antibiotics showed improvement of collagen induced arthritis in vivo.

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