Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis III. Physico-chemical Properties and Structure Determination

NAOKI MATSUMOTO; TOSHIO TSUCHIDA; RYUICHI SAWA; HIRONOBU IINUMA; HIKARU NAKAMURA; HIROSHI NAGANAWA; TSUTOMU SAWA; TOMIO TAKEUCHI

doi:10.7164/antibiotics.50.912

Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis

III. Physico-chemical Properties and Structure Determination

NAOKI MATSUMOTO, TOSHIO TSUCHIDA, RYUICHI SAWA, HIRONOBU IINUMA, HIKARU NAKAMURA, HIROSHI NAGANAWA, TSUTOMU SAWA, TOMIO TAKEUCHI

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 11 Pages 912-915

DOI https://doi.org/10.7164/antibiotics.50.912

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Abstract

The structures of epoxyquinomicins A (1), B (2), C (3) and D (4) were determined by spectroscopic studies. Compound 1 was determined to be (5R, 6S)-2-(3-chloro-2-hydroxybenzoylamino)-5-hydroxymethyl-5, 6-epoxy-2-cyclohexene-1, 4-dione. Compound 2 was revealed to be the dechlorinated derivative of 1. Compounds 3 and 4 were determined to be the reduced derivative of 2 and 1, respectively.

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