Pterulinic Acid and Pterulone, Two Novel Inhibitors of NADH: Ubiquinone Oxidoreductase (Complex I) Produced by a Pterula Species
I. Production, Isolation and Biological Activities
1997 年 50 巻 4 号 p. 325-329
詳細
1997 年 50 巻 4 号 p. 325-329
Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH: ubiquinone oxidoreductase (complex I).
