Phenochalasins, Inhibitors of Lipid Droplet Formation in Mouse Macrophages, Produced by Phomopsis sp. FT-0211

HIROSHI TOMODA; ICHIJI NAMATAME; SHUYI SI; KOTARO KAWAGUCHI; ROKURO MASUMA; MICHIO NAMIKOSHI; SATOSHI OMURA

doi:10.7164/antibiotics.52.851

Phenochalasins, Inhibitors of Lipid Droplet Formation in Mouse Macrophages, Produced by Phomopsis sp. FT-0211

HIROSHI TOMODA, ICHIJI NAMATAME, SHUYI SI, KOTARO KAWAGUCHI, ROKURO MASUMA, MICHIO NAMIKOSHI, SATOSHI OMURA

著者情報

ジャーナルフリー

1999 年 52 巻 10 号 p. 851-856

DOI https://doi.org/10.7164/antibiotics.52.851

詳細

抄録

Phomopsis sp. FT-0211, a soil isolate, was found to produce inhibitors of Hpid droplet formation in mouse peritoneal macrophages. Structurally related new compounds designated phenochalasins A and B were isolated from the fermentation broth of the producing strain by solvent extraction, ODS column chromatography and preparative HPLC. Phenochalasin A caused a dose-dependent reduction in the number and size of lipid droplets in macrophages without any cy to toxic effect at least up to 20 μM. On the other hand, phenochalasin B showed inhibition of lipid droplet formation with a severe cytotoxic effect on macrophages.

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