New Cytotoxic AgentsvBE-54238A and B, Produced by a Streptomycete

MASAO TSUKAMOTO; SHIGERU NAKAJIMA; KUMIKO MUROOKA; MIOKO HIRAYAMA; KAORI HIRANO; SHIGEMI YOSHIDA; KATSUHISA KOJIRI; HIROYUKI SUDA

doi:10.7164/antibiotics.53.26

MASAO TSUKAMOTO, SHIGERU NAKAJIMA, KUMIKO MUROOKA, MIOKO HIRAYAMA, KAORI HIRANO, SHIGEMI YOSHIDA, KATSUHISA KOJIRI, HIROYUKI SUDA

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ジャーナルフリー

2000 年 53 巻 1 号 p. 26-32

DOI https://doi.org/10.7164/antibiotics.53.26

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抄録

New cytotoxic substances, designated BE-54238A and B, were isolated from the culture broth of Streptomyces sp. A54238. The active principles were extracted from the mycelium by methanol and purified by Diaion HP-20 and Sephadex LH-20 column chromatographies. BE-54238A and B exhibited cytotoxic activity against murine and human tumor cell lines.

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