Quinolactacins A, B and C: Novel Quinolone Compounds from Penicillium sp. EPF-6 I. Taxonomy, Production, Isolation and Biological Properties

NORIHIRO KAKINUMA; HIROKI IWAI; SENJI TAKAHASHI; KUNIKATSU HAMANO; TADASHI YANAGISAWA; KOJI NAGAI; KOICHI TANAKA; KENICHI SUZUKI; FUMIKO KIRIKAE; TERUO KIRIKAE; AKIRA NAKAGAWA

doi:10.7164/antibiotics.53.1247

Quinolactacins A, B and C: Novel Quinolone Compounds from Penicillium sp. EPF-6

I. Taxonomy, Production, Isolation and Biological Properties

NORIHIRO KAKINUMA, HIROKI IWAI, SENJI TAKAHASHI, KUNIKATSU HAMANO, TADASHI YANAGISAWA, KOJI NAGAI, KOICHI TANAKA, KENICHI SUZUKI, FUMIKO KIRIKAE, TERUO KIRIKAE, AKIRA NAKAGAWA

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ジャーナルフリー

2000 年 53 巻 11 号 p. 1247-1251

DOI https://doi.org/10.7164/antibiotics.53.1247

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抄録

Quinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have been found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid (Margaronia pyloalis Welker). The fungal strain, EPF-6 was identified as Penicillium sp. from its morphological characteristics. Quinolactacins were obtained from the culture medium by solvent extraction and chromatographic purification. Compound 1 showed inhibitory activity against tumor necrosis factor (TNF) production induced by murine peritoneal macrophages and macrophage-like J774.1 cells stimulated with lipopolysaccharide (LPS).

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