Fermentation Microbiology Laboratory, Biology Department, Massachusetts Institute of Technology
GRACE K. WONG
Fermentation Microbiology Laboratory, Biology Department, Massachusetts Institute of Technology Present address: University of Hawaii, John A. Burns School of Medicine
ARNOLD L. DEMAIN
Fermentation Microbiology Laboratory, Biology Department, Massachusetts Institute of Technology
Streptomyces hygroscopicus ATCC 29253 produces rapamycin, elaiophylin and nigericin. Although elaiophylin has no activity against Candida albicans ATCC 11651, it markedly enhances rapamycin's antifungal activity. Nigericin has only weak activity on its own but it also enhances rapamycin action. Surprisingly, elaiophylin does not enhance nigericin activity on C. albicans.
