IB-96212, a Novel Gytotoxic Macrolide Produced by a Marine Micromonospora I. Taxonomy, Fermentation, Isolation and Biological Activities

ROSA ISABEL FERNÁNDEZ-CHIMENO; LIBRADA CAÑEDO; FERNANDO ESPLIEGO; DOLORES GRÁVALOS; FERNANDO DE LA CALLE; JOSÉ LUIS FERNÁNDEZ-PUENTES; FRÁNCISCO ROMERO

doi:10.7164/antibiotics.53.474

IB-96212, a Novel Gytotoxic Macrolide Produced by a Marine Micromonospora

I. Taxonomy, Fermentation, Isolation and Biological Activities

ROSA ISABEL FERNÁNDEZ-CHIMENO, LIBRADA CAÑEDO, FERNANDO ESPLIEGO, DOLORES GRÁVALOS, FERNANDO DE LA CALLE, JOSÉ LUIS FERNÁNDEZ-PUENTES, FRÁNCISCO ROMERO

著者情報

ジャーナルフリー

2000 年 53 巻 5 号 p. 474-478

DOI https://doi.org/10.7164/antibiotics.53.474

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抄録

A novel bioactive macrolide, IB-96212 has been isolated from the fermentation broth of a marine actinomycete, L-25-ES25-008. The strain belongs to the genus Micromonospora. The macrolide showed a very strong cytotoxic activity against P-388, and lower but significant activity against A-549, HT-29, and MEL-28 cell lines. We describe the isolation, taxonomy and fermentation of the producing strain as well as the isolation of IB-96212.

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