Luminacins: A Family of Capillary Tube Formation Inhibitors from Streptomyces sp. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation

NOBUAKI NARUSE; RENA KAGEYAMA-KAWASE; YASUHIRO FUNAHASHI; TOSHIAKI WAKABAYASHI; YOSHIO WATANABE; TOMOHIRO SAMESHIMA; KAZUYUKI DOBASHI

doi:10.7164/antibiotics.53.579

Luminacins: A Family of Capillary Tube Formation Inhibitors from Streptomyces sp.

I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation

NOBUAKI NARUSE, RENA KAGEYAMA-KAWASE, YASUHIRO FUNAHASHI, TOSHIAKI WAKABAYASHI, YOSHIO WATANABE, TOMOHIRO SAMESHIMA, KAZUYUKI DOBASHI

著者情報

ジャーナルフリー

2000 年 53 巻 6 号 p. 579-590

DOI https://doi.org/10.7164/antibiotics.53.579

詳細

抄録

A new family of capillary tube formation inhibitors, designated luminacins, has been discovered in the fermentation broth of a soil bacterium. The strain was identified as Streptomyces sp. Mer-VD1207 from taxonomic studies. By means of a series of chromatographic procedures, fourteen structurally related components, luminacins A₁, A₂, B₁, B₂, C₁, C₂, D, E₁, E₂, E₃, F, G₁, G₂, and H, were isolated, and their structures were elucidated on the basis of spectroscopic analyses.

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