Discovery of Novel Ansamycins Possessing Potent Inhibitory Activity in a Cell-based Oncostatin M Signalling Assay

PAUL STEAD; SHAZIA LATIF; ANDREW P. BLACKABY; PHILIP J. SIDEBOTTOM; ANGELA DEAKIN; NICHOLAS L. TAYLOR; PAUL LIFE; JOHN SPAULL; FIONA BURRELL; ROSIE JONES; JANE LEWIS; IAN DAVIDSON; THOMAS MANDER

doi:10.7164/antibiotics.53.657

PAUL STEAD, SHAZIA LATIF, ANDREW P. BLACKABY, PHILIP J. SIDEBOTTOM, ANGELA DEAKIN, NICHOLAS L. TAYLOR, PAUL LIFE, JOHN SPAULL, FIONA BURRELL, ROSIE JONES, JANE LEWIS, IAN DAVIDSON, THOMAS MANDER

著者情報

ジャーナルフリー

2000 年 53 巻 7 号 p. 657-663

DOI https://doi.org/10.7164/antibiotics.53.657

詳細

抄録

We describe the isolation and characterisation of novel non-benzoquinone ansamycin metabolites related to geldanamycin from a culture of Streptomyces sp. S6699. The compounds possess potent inhibitory activity in a cell-based assay measuring inhibition of oncostatin M signalling in a reporter cell line utilising a secreted placental alkaline phosphatase (sPAP) readout. In this paper we report the isolation and structure elucidation of the compounds and describe some of their biological properties.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）