Diheteropeptin, a New Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia I. Production, Isolation and Biological Activities

YUHTA MASUOKA; KAZUO SHIN-YA; YONG-BAE KIM; MINORU YOSHIDA; KOJI NAGAI; KEN-ICHI SUZUKI; YOICHI HAYAKAWA; HARUO SETO

doi:10.7164/antibiotics.53.788

Diheteropeptin, a New Substance with TGF-β-like Activity, Produced by a Fungus, Diheterospora chlamydosporia

I. Production, Isolation and Biological Activities

YUHTA MASUOKA, KAZUO SHIN-YA, YONG-BAE KIM, MINORU YOSHIDA, KOJI NAGAI, KEN-ICHI SUZUKI, YOICHI HAYAKAWA, HARUO SETO

著者情報

ジャーナルフリー

2000 年 53 巻 8 号 p. 788-792

DOI https://doi.org/10.7164/antibiotics.53.788

詳細

抄録

A new metabolite, diheteropeptin, was found in the culture broth of Diheterospora chlamydosporia Q58044 by screening for TGF-β-like active substances. Diheteropeptin was extracted from the culture supernatant and purified by a series of chromatographies such as silica gel, gel filtration and HPLC. Diheteropeptin exhibited cytostatic activity in MvlLu cells with an IC₅₀ value of 20.3 μM and inhibited histone deacetylase.

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