EI-2346, a Novel Interleukin-1β Converting Enzyme Inhibitor Produced by Streptomyces sp. E-2346 I. Taxonomy of Producing strain, Fermentation, Isolation, Physico-chemical Properties, and Biological Properties

FUMITO KOIZUMI; ATSUHIRO HASEGAWA; KEIKO OCHIAI; KATSUHIKO ANDO; HIDEMASA KONDO; MAYUMI YOSHIDA; YUZURU MATSUDA; SATOSHI NAKANISHI

doi:10.7164/antibiotics.56.985

EI-2346, a Novel Interleukin-1β Converting Enzyme Inhibitor Produced by Streptomyces sp. E-2346

I. Taxonomy of Producing strain, Fermentation, Isolation, Physico-chemical Properties, and Biological Properties

FUMITO KOIZUMI, ATSUHIRO HASEGAWA, KEIKO OCHIAI, KATSUHIKO ANDO, HIDEMASA KONDO, MAYUMI YOSHIDA, YUZURU MATSUDA, SATOSHI NAKANISHI

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ジャーナルフリー

2003 年 56 巻 12 号 p. 985-992

DOI https://doi.org/10.7164/antibiotics.56.985

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抄録

EI-2346, a novel interleukin-1β converting enzyme (ICE) inhibitor, was isolated from the culture broths of Streptomyces sp. E-2346. EI-2346 selectively inhibited the human recombinant ICE activity with an IC₅₀ value of 3.9μM, without inhibiting elastase and cathepsin B. EI-2346 also inhibited mature interleukin-1β secretion from THP-1 cells induced by LPS with an IC₅₀ value of 5.2μM.

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