Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp. I. Taxonomy, Fermentation and Biological Activities

WENYING LI; JOHN E. LEET; HELEN A. AX; DONALD R. GUSTAVSON; DANIEL M. BROWN; LAURA TURNER; KIMBERLY BROWN; JUNIUS CLARK; HYEKYUNG YANG; JOAN FUNG-TOMC; KIN S. LAM

doi:10.7164/antibiotics.56.226

Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp.

I. Taxonomy, Fermentation and Biological Activities

WENYING LI, JOHN E. LEET, HELEN A. AX, DONALD R. GUSTAVSON, DANIEL M. BROWN, LAURA TURNER, KIMBERLY BROWN, JUNIUS CLARK, HYEKYUNG YANG, JOAN FUNG-TOMC, KIN S. LAM

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JOURNAL FREE ACCESS

2003 Volume 56 Issue 3 Pages 226-231

DOI https://doi.org/10.7164/antibiotics.56.226

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Abstract

Thiazolyl peptide antibiotics, nocathiacin I, II and III, were identified in a culture of Nocardia sp. WW-12651 (ATCC 202099). They exhibit potent in vitro activity (ng/ml) against a wide spectrum of Gram-positive bacteria, including multiple-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant Enterococcus faecium (MREF) and fully penicillin-resistant Streptococcus pneumoniae (PRSP), and demonstrate excellent in vivo efficacy in a systemic Staphylococcus aureus infection mice model.

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