Abstract
1) The half-life of serum concentration of cephradine (CED) in patients with normal renal function, was 30 minutes and it prolonged to 83 minutes when combined with probenecid.
2) In the patients with severely impaired renal function, mean serum concentration of CED was 33 mcg/ml 24 hours after 1g intravenous injection.
3) In clinical observations of 17 cases with infections of lung, urinary tract, and bile duct, the treatment with CED showed excellent results in 5 cases, good in 6, undetermined in 1. No remarkable side effect was observed.
