最新の抗生物質IXCefroxadine
1982 年 35 巻 6 号 p. 1365-1373
詳細
1982 年 35 巻 6 号 p. 1365-1373
The antibacterial spectrum of cefroxadine was as wide as that of CEX, and its antibacterial effect was as strong as that of CEX or even 2-fold stronger against E.coli and Klebsiella.Cefroxadine was also proved to have stronger bactericidal or bacteriolytic effect than CEX and have better affinity with penicillin binding proteins.In clinical trials, an efficacy rate of82.7% was achived in a total of2,009cases of various infections analyzed.Cefroxadine displayed particularly good clinical and bacteriological effects for the infections of skin, soft tissues, respiratory tract and urinary tract.The rate of bacteria eradication in a total of1,410cases was 81.6%, showing good results against the bacteria such as S.aureus (83.9%, 167/199), E.coli (89.0%, 528/593), Klebsiella (78.0%, 78/100) and P.mirabilis (80.0%, 36/45).As for side effects, their incidence was a low of only2.3%, the main ones being eruption and gastrointestinal symptoms just as recognized in conventional cephalosporins, and none of them was serious.Abnormal laboratory test values were only increases in eosinophil, SGOT, S-GPT and Al-P values, and their incidence was low.
From these findings, we may say that the drug is an effective, safe, and useful antibiotic among all other orally administered cephalosporins.
