Fortimicinの産婦人科領域における臓器内移行濃度について
1982 年 35 巻 6 号 p. 1399-1401
詳細
1982 年 35 巻 6 号 p. 1399-1401
A new aminoglycoside antibiotic, fortimicin, was administered intramuscularly at a dose of 200 mg, and the tissue distribution of the drug was investigated with time-course in the uterine fundus, uterine cervix, oviduct, endometrium and ovary.
Patients who required total hysterectomy or uterine appendices resection due to uterine myoma,etc. were studied.
The uterus levels of fortimicin were about 2 mcg/g at 2 hours after intramuscular administration in the uterine fundus and uterine cervix and reduced to trace after 8-9 hours.
The genital organs levels of fortimicin were ranged from 0.71 to 4.6 mcg/g at 1-3 hours after intramuscular administration and then reduced to the levels of 0.79 mcg/g in the oviduct, of 0.25 mcg/g in the endometrium and of 0.45mcg/g in the ovary after 5 hours.
