THE WHOLE BODY AUTORADIOGRAPHIC STUDIES ON THE DISTRIBUTION OF C-LABELLED SODIUM 7β-[(2R, 3S)-2-(4-ETHYL-2, 3-DIOX0-1-PIPERAZINE-¹⁴ CARBOXAMIDO)-3-HYDROXYBUTANAMID0]-7α-METHOXY-3-[(1-METHYL-1H-TETRAZOL-5-YL) THIO METHYL]-3-CEPHE M-4-CARBOXYLATE (¹⁴C-T-1982) IN MICE

Abstract

The distribution of T-1982, a new semisynthetic cephamycin antibiotic, was studied with whole body autoradiography in normal male mice, pregnant mice and experimental pyelonephritic mice following a single intravenous administration of 80 mg/kg of ¹⁴C-T-1982.
1.In normal male mice, the radioactivity was distributed at high concentration in the liver, kidney, lung, gastrointestinal tracts, skin, salivary gland, tongue and muscle, but was hardly observed in the central nervous system that composed of the brain and spinal cord.
2.In pregnant mice, the radioactivity was hardly observed in the fetuses.
3.In experimental pyelonephritic mice, considerable radioactivity was concentrated on the acute inflammatory area.