A CLINICAL STUDY ON CEFOPERAZONE IN SERIOUS INFECTIONS ASSOCIATED WITH HEMATOLOGICAL MALIGNANCY

Abstract

Clinical and bacteriological efficiencies of cefoperazone (CPZ) in 19 serious infections associated with hematological malignancy were studied.
1. CPZ was clinically effective in 13 cases (68.4%). Excellent effects were obtained in 3 cases (15.8%), good effects in 7 cases (36.8%) and fairly good effects in 3 cases (15.8%). The rate of clinical effectiveness by CPZ was not dependent on neutrophils number in peripheral blood.
2. Bacteriological effectiveness to isolated organisms in 15 cases was obtained in 9 cases (60%).
3. Clinically significant serum concentrations of CPZ persisted over 6 hours after injection (1g/l hour, d. i. v.). In comparative study of MIC against clinically isolated P. aeruginosa, CPZ was superior to other cephalosporins.
4. Adverse reactions were not significant except for 3 cases with abnormalities of hepatic function.