Abstract
Pharmacokinetic studies were carried out on cefbuperazone (CBPZ) in 9 patients postoperating under-going drainage. The concentration of CBPZ in serum and peritoneal exudate after one shot intravenous administration of 1g was measured by bioassay and calculated respectively by two-and one-compartment open model. The results obtained were as follows:
1. The pharmacokinetic parameters calculated from the serum levels were compared to those reported previously; T1/2=101min., Vd=4.06L and Cl=76ml/min.
2. The simulation curve of the peritoneal exudate level fit fairly with the mean values of 6 patients. It appeared that CBPZ penetrated somewhat slowly into peritoneal exudate with the peak value of 27.05μg/ml at about 1 hour after the administration. The exudate levels thereafter declined more slowly than the serum ones (T1/2=134min.). It was 6.2μg/ml even at 6 hours after the administration.
