TOXICOLOGICAL STUDIES ON A NEW MACROLIDE ANTIBIOTIC, MIDECAMYCIN ACETATE (MIOCAMYCIN)

PART IV-4. TOXICITY OF METABOLITES OF MIOCAMYCIN: ACUTE TOXICITY OF Mb₂ IN MICE

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Miocamycin (MOM) is a derivative of midecamycin1, 2) and is metabolized into 4 main metabolites5). At previous study, LD₀ values of Mb₁ were estimated more than 5,000 mg/kg in male and female mice7).
The object of this study was to evaluate acute toxicity in male and female mice after single oral administration of Mb₂, a metabolite of MOM, at a does level of 5,000 mg/kg as the maximum physically applicable dose. It is concluded that LD, values of Mb₂ were estimated more than 5,000 mg/kg.