急性化膿性腹膜炎よりの分離菌とそめ薬剤感受性について

品川 長夫; 水野 章; 真下 啓二; 由良 二郎; 石川 周; 平田 公一; 傳野 隆一; 向谷 充宏; 石引 久彌; 相川 直樹; 田熊 清継; 田中 隆; 岩井 重富; 田中 日出和; 木下 博明; 森本 健; 藤本 幹夫; 谷村 弘; 大西 博信; 野口 浩平; 溝端 静馬; 梅本 善哉; 折田 薫三; 井上 文之; 淵本 定義; 木村 秀幸; 小長 英二; 松浦 雄一郎; 児玉 節; 横山 隆; 檜山 英三; 池田 靖洋; 山本 博; 安波 洋一; 出口 浩一

doi:10.11553/antibiotics1968b.47.1329

BACTERIA ISOLATED FROM INTRAABDOMINAL INFECTION AND THEIR SUSCEPTIBILITIES TO ANTIMICROBIAL AGENTS

NAGAO SHINAGAWA, AKIRA MIZUNO, KENJI MASHITA, JIRO YURA, SYU ISHIKAWA, KOICHI HIRATA, RYUICHI DENNO, MITSUHIRO MUKAIYA, KYUYA ISHIBIKI, NAOKI AIKAWA, KIYOTSUGU TAKUMA, TAKASHI TANAKA, SHIGETOMI IWAI, HIDEO TANAKA, HIROAKI KINOSHITA, KEN MORIMOTO, MIKIO FUJIMOTO, HIROSHI TANIMURA, HIRONOBU OHNISHI, KOHEI NOGUCHI, SHIZUMA MIZOBATA, YOSHIYA UMEMOTO, KUNZO ORITA, FUMIYUKI INOUE, SADAYOSHI FUCHIMOTO, HIDEYUKI KIMURA, EIJI KONAGA, YUUICHIRO MATSUURA, TAKASHI KODAMA, TAKASHI YOKOYAMA, EIZO HIYAMA, SEIYO IKEDA, HIROSHI YAMAMOTO, YOHICHI YASUNAMI, KOICHI DEGUCHI

Author information

NAGAO SHINAGAWA
The First Department of Surgery, Nagoya City University Medical School
AKIRA MIZUNO
The First Department of Surgery, Nagoya City University Medical School
KENJI MASHITA
The First Department of Surgery, Nagoya City University Medical School
JIRO YURA
Center of Digestive Diseases, Matsunami Hospital
SYU ISHIKAWA
Department of Surgery, Midori Municipal Hospital
KOICHI HIRATA
The First Department of Surgery, Sapporo Medical College
RYUICHI DENNO
The First Department of Surgery, Sapporo Medical College
MITSUHIRO MUKAIYA
The First Department of Surgery, Sapporo Medical College
KYUYA ISHIBIKI
Department of Surgery, School of Medicine, KeioUniversity
NAOKI AIKAWA
Department of Emergency Medicine, School of Medicine, Keio University
KIYOTSUGU TAKUMA
Department of Emergency Medicine, School of Medicine, Keio University
TAKASHI TANAKA
The Third Department of Surgery, Nihon University School of Medicine
SHIGETOMI IWAI
The Third Department of Surgery, Nihon University School of Medicine
HIDEO TANAKA
The Third Department of Surgery, Nihon University School of Medicine
HIROAKI KINOSHITA
The Second Department of Surgery, Osaka City University School of Medicine
KEN MORIMOTO
The Second Department of Surgery, Osaka City University School of Medicine
MIKIO FUJIMOTO
Department of Surgery, Fujiidera Municipal Hospital
HIROSHI TANIMURA
Department of Gastroenterological Surgery, Wakayama Medical College
HIRONOBU OHNISHI
Department of Gastroenterological Surgery, Wakayama Medical College
KOHEI NOGUCHI
Department of Gastroenterological Surgery, Wakayama Medical College
SHIZUMA MIZOBATA
Department of Gastroenterological Surgery, Wakayama Medical College
YOSHIYA UMEMOTO
Department of Gastroenterological Surgery, Wakayama Medical College
KUNZO ORITA
The First Department of Surgery, Okayama University School of Medicine
FUMIYUKI INOUE
Department of Surgery, Cyuden Hospital
SADAYOSHI FUCHIMOTO
Department of Surgery, Cyuden Hospital
HIDEYUKI KIMURA
Department of Surgery, Okayama Saiseikai Hospital
EIJI KONAGA
Department of Surgery, National Iwakuni Hospital
YUUICHIRO MATSUURA
The First Department of Surgery, Hiroshima University School of Medicine
TAKASHI KODAMA
Department of General Clinic, Hiroshima University, School of Medicine
TAKASHI YOKOYAMA
Department of General Clinic, Hiroshima University, School of Medicine
EIZO HIYAMA
The First Department of Surgery, Faculty of Medicine, Fukuoka University
SEIYO IKEDA
The First Department of Surgery, Faculty of Medicine, Fukuoka University
HIROSHI YAMAMOTO
Section of Studies, Tokyo Clinical Research Center
YOHICHI YASUNAMI
Section of Studies, Tokyo Clinical Research Center
KOICHI DEGUCHI
Section of Studies, Tokyo Clinical Research Center

JOURNAL FREE ACCESS

1994 Volume 47 Issue 10 Pages 1329-1343

DOI https://doi.org/10.11553/antibiotics1968b.47.1329

Details

Abstract

Bacteria isolated from intraabdominal infections during the period from July 1982 to June 1993 were investigated with regard to their classifications according to a joint research by 9 university hospitals in Japan. The following results were obtained.
1. A total of 971 strains were isolated from 684 out of 597 patients with peritonitis, and 287 strains out of 971 were isolated from postoperative peritonitis.
2. The most predominant organism isolated from patients with acute peritonitis was Escherichia coli (28%), followed by Bacteroides fragilis group (17%), Gram-positive anaerobic cocci (16%), Enterococcus spp.(9%) and Klebsiella spp.(8%).
3. Against E. coli, cefmenoxime, cefuzonam, cefozopran, aztreonam and carumonam showed MIC₅₀ less than 0.05μ/ml. Against B. fragilis group, erythromycin, clindamycin, imipenem, lincomycin and latamoxef showed MIC₅₀ less than 0.78μ/ml.
4. The most predominant organism isolated from patients with postoperative peritonitis was Enterococcus spp.(20%) and followed by Pseudomonas spp.(14%), and Staphylococcus spp.(13%), E. coli (9%), Enterobacter spp.(8%) and Klebsiella spp.(8%).
We suggest that cefazolin, cefmetazole, flomoxef, cefmenoxime, cefuzonam and latamoxef are the first choice agents in empiric therapy for the treatment of acute peritonitis.

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