Bundlins A and B, Two Antibiotics Produced by Streptomyces Griseofuscus Nov. Sp.

Abstract

Two crystalline antibiotics named bunlins A and B have been isolated from culture broth of Streptomyces No. 1068 obtained from the soil near Dake hot spring, Fukushima Prefecture, Japan. Bundlin A is mainly active against Sarcina lutea and similar to lankacidin¹⁾. Bundlin B is a new antibiotic of a week and narrow antimicrobial spectrum.

In the previous paper, Sakamoto^2,3) reported that two yellow crystalline antifungal antibiotics, moldcidins A and B, produced by Streptomyces No. 1069. Moldcidin A was pentaene antibiotic containing about 1.5% nitrogen. Moldcidin B was pentaene type containing no nitrogen and identical pentamycin^4,5).

Since the Streptomyces No. 1068 is unlike any of the Streptomyces described in Bergey’s Manual of Determinative Bacteriology (1957), we propose to name the organism Streptomyces griseofuscus nov. sp.