1963 年 16 巻 2 号 p. 59-66
A number of antibiotic substances derived from Streptomyces cultures, which appear to be related bioligically and chemically to erythromycin or carbomycin, have been reported to date. They are colorless bases, active mainly against Gram-positive bacteria and have similar patterns of cross resistance. They have been grouped together as macrolide antibiotics.
In the course of systematic screening for new antibiotics, a new strain, Strptomyces sp. No. 12090, was isolated which in submerged culture produces a new antibiotic, cirramycin, belonging to the macrolide group antibiotics.
This paper deals with the producing strain, production, isolation, as well as biological and physico-chemical properties of cirramycin. This antibiotic contains at least two components, A and B, which were separated by counter-current distribution. When no reference is made to either A or B, the material used was a mixture containing approximately equal amount of A and B components.
