The Effect of Oxytetracycline on the Carbohydrate Metabolism of Streptomyces Rimosus Variants

抄録

Nyiri¹⁾ had observed a partial cross inhibition (pseudoantagonism) between oxytetracycline-producing (active) and non-producing (inactive) Streptomyce rimosus variants. Due to the concentration of oxytetracycline the inactive variant showed different reactions: until in the case of low antibiotic concentration germination of spores and the development of young hyphae was restricted by the elder hyphae were induced to produce oxytetracycline.

To reveal the biochemical causes of these phenomena experiments were carried out to determine the effect of oxytetracycline on the metabolism of Streptomyces rimosus.

Considering the mode of action of this antibiotic on the bacterial metabolism, the effect of respiratory and/or oxidative phosphorylation system seemed to presumable. Accordingly experiments were at first designed to study the effects of oxytetracycline on the carbohydrate metabolism of oxytetracycline-producing and non-producing Streptomyces rimosus variants.