Studies on Pyrrolnitrin, a New Antibiotic. I Isolation and Properties of Pyrrolnitrin

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In the course of screening of antibiotics, a new antibiotic was obtained from the cells of a bacterium which was isolated from a soil sample collected in Chiba Prefecture, Japan.

The cultural characteristic of the bacterium was investigated by the authors¹⁾. The antibiotic was named pyrrolnitrin and isolated as pale yellow crystals. Pyrrolnitrin has a growth inhibitory effect against fungi, yeasts and Gram-positive bacteria, and has low toxicity.

This paper deals with fermentation, isolation and properties of pyrrolnitrin.