Abstract
As the effects of Histidine in the diet on the secretory function of gastric gland cells were investigated in author's former study, the author has studied here if the actional mechanisms of Histidine are similar to those of Histamine, and has obtained the following conclusions.
1. The production of secretion granules in the peptic cells is believed to be promoted by Histamine and not by Histidine.
2. Histamine does not promote the discharge of productin from the gastric surface cells but Histidine does actively promote it. Accordingly, Histidine seems as if it would promote the production of secretion granules in the peptic cells if man observed only the peptic cells.
3, Histidine seems to be related to the vacuolization of secretion granules (discharging stage of secretion granules) in the peptic cells.
4. The actional difference between Histidine and Histamine is deduced to be owing to the side chain combined with the imidazol group.
