A Histochemical Study on Several Organs of Mouse after Injection of Chlorpromazine

Abstract

Chlorpromazine gave multiple influences on the histochemical findings in several organs of mouse, as it was expected to some extent. Those histochemical changes were usually the most intense in the case of three hours after injection.
1. Alkaline phosphatase activity was depressed by chlorpromazine on the small intestine and kidney but not on the submaxillary gland and on the KUPFFER cells of the liver.
2. Stainability by PAS method was increased slightly in the clear cells of the submaxillary gland and in the epithelium of the small intestine. The PAS positive granules of liver cells were decreased distinctly after injection of chlorpromazine.
3. Stainability by Hg-BPB method was demonstrated in the dark cells of submaxillary gland, in the striated border of small intestine, in liver cells and in the thick segment of loop of HENLE. The stainable substances in these cells was decreased more or less after injection with chlorpromazine.