Antiphlogistic and Antianaphylactic Activity of Detergent

Abstract

In the previous report it was found that necrotizing factor in the serum had a property of easily combining with the tissue, and that inhibitors against protein denaturation also inhibited the biological activity of the necrotizing factor. Therefore it is considered that some of inhibitors against denaturation, such as an anionic detergent, could be an anti-inflammatory drug. In the present work, inflammatory edema induced by caolin or formalin in rats was markedly inhibited by an anionic detergent, such as Na dodecyl sulfate or Na dodecyl benzene sulfonate given intraperitoneously before the injection of caolin or formalin. On the other hand phenylbutazone and salicylate, especially the former, inhibited the coagulation of serum or egg albumin by heat at a low concentration, while other antipyretic and analgetic agents showed comparatively very weak or no inhibitory action against the coagulation of albumin. l0^<-5>M Na dodecyl sulfate inhibited the hemolysis of sheep erythrocytes by hemolytic amboceptor.