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Volume 12, Issue 3-4
Displaying 1-11 of 11 articles from this issue
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Article type: Cover
1963 Volume 12 Issue 3-4 Pages Cover5-
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (331K) -
Article type: Cover
1963 Volume 12 Issue 3-4 Pages Cover6-
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (331K) -
Article type: Appendix
1963 Volume 12 Issue 3-4 Pages App4-
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (344K) -
Takanori TsudaArticle type: Article
1963 Volume 12 Issue 3-4 Pages 83-98,134
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn relation to the renal changes in the "collagen disease", an experiment was carried out to clarify the pathogenetic mechanism of the so-called "lupus nephritis" by means of the provocation of the active anaphylaxis in the kidney of the rabbit sensitized with bovine serum gamma globulin. Based upon the Hamamoto's theory of "Intravascular Antigen-Antibody Reaction", the bovine gamma globulin solution was injected directly through the renal artery into the kidney of the rabbit whose serum titer against the bovine gamma globulin was sufficiently high. Rabbits were sacrificed from one day to twenty days after the provocative injection, and then the pathohistological changes of the kidney were examined. Major pathohistological changes of the kidney were as follows: 1) Dramatic exsudative and necrotizing inflammatory changes of the glomerular capillaries in early stage, 2) Thickening of the capillary basement membranes which were often irregular, 3) Lesion of the proliferative glomerulonephritis 4) Glomerular fibrosis and glomerular cicatrization 5) Hyaline droplet degeneration of the tubuli 6) Desquamation of the tubular epithelial cells 7) Necrotizing arteritis in small arteries 8) Perivascular infiltration of monohistiocytes and leucocytes 9) Proliferation and degeneration of endothelial cells of capillaries and arteries. These pathohistological changes resembled the renal changes in systemic lupus erythematosus which stand for "collagen disease". These observation indicate that the renal changes in collagen disease may be of "allergic" mechanisms.View full abstractDownload PDF (2838K) -
Yutaka Mizushima, Reiji KasukawaArticle type: Article
1963 Volume 12 Issue 3-4 Pages 99-102,134
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn the previous report it was found that necrotizing factor in the serum had a property of easily combining with the tissue, and that inhibitors against protein denaturation also inhibited the biological activity of the necrotizing factor. Therefore it is considered that some of inhibitors against denaturation, such as an anionic detergent, could be an anti-inflammatory drug. In the present work, inflammatory edema induced by caolin or formalin in rats was markedly inhibited by an anionic detergent, such as Na dodecyl sulfate or Na dodecyl benzene sulfonate given intraperitoneously before the injection of caolin or formalin. On the other hand phenylbutazone and salicylate, especially the former, inhibited the coagulation of serum or egg albumin by heat at a low concentration, while other antipyretic and analgetic agents showed comparatively very weak or no inhibitory action against the coagulation of albumin. l0^<-5>M Na dodecyl sulfate inhibited the hemolysis of sheep erythrocytes by hemolytic amboceptor.View full abstractDownload PDF (671K) -
Teruo IrieArticle type: Article
1963 Volume 12 Issue 3-4 Pages 103-115,135
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSContinuing the investigation of the previous report, the author reported on the macroscopical and histological changes in the spleen caused on the active anaphylaxis, which was a part of studies on the intravascular antigen-antibody reaction of thrombocyte. On the experimental method, normal rabbits were immunized frequently with the normal dog platelets. Thereafter, rabbits were operated by means of laparotomy and the provocative injection was administered into the splenic artery with the normal dog platelets (Experimental Group A). On the other hand, the normal dog platelets were injected into the marginal ear vein of immunized rabbits (Experimental Group B) Rabbits were sacrificed and autopsied periodically from twenty-four hours to two weeks after the provocative injection and the macroscopical and histological changes of spleen were examined. In the experimental group A, no remarkable macroscopical changes were found. In the histlogical observation, the following remarkable changes were found: hyperplasia of lymph follicles, congestion and dilatation of sinus, swelling of the sinus endothelial cells, inflammatory leukocytic infiltration, erythro- and thrombophagocytosis, hemosiderosis, appearance of megakaryocytes in the sinus, some foci of extramedullary hemopoiesis and edema in the trabecular. In the experimental group B, macroscopical changes were not found. Histological changes were observed similar to those in the experimental group A, but degree of the damages were slight.View full abstractDownload PDF (2380K) -
Norimichi NakazimaArticle type: Article
1963 Volume 12 Issue 3-4 Pages 116-124,135-13
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSIn this paper the author presents a method to induce passive cutaneous anaphylaxis of guinea pigs to penicillin and discusses the mechanism of antigenic binding of penicillin to albumin. Penicillin G and recrystallized egg white albumin were incubated at 37℃ for 24 hours. The precipitates obtained by incubation were centrifuged and desolved in buffered saline (pH 7.6 to 7.8). All rabbit antisera of 8 to 10 weeks sensitization by these penicillin-albumin conjugated yielded high titer (1,000 times dilution) of P.C.A. reaction. Antigenic properties of penicillin were simple hapten as observed in the ileum contraction test of actively sensitized guinea pigs. As far the mechanism of antigenic binding of penicillin to albumin, after incubation of penicillin G and albumin at 37℃ for 24 hours, the pH of the medium decreased from 6.2 to 4.6. By making the medium alkaline the P.C.A. titer was almost completely lost. On the contrary, by acidification the binding process was accelerated. The incubated mixture of penicillin G and tissue homogenates such as liver, spleen, lung and skin did not induce P.C.A., with the exception of the exsudates, which usually have acid reaction. Normal serum incubated with penicillin G gave no positive result, but after acidification and dialysis positive reaction was observed. Benzyl penicillenic acid, a intermediate degradation product of penicillin G was reported to be a chemically active substance, which binds easily certain aminoacid residures of protein molecule. Benzyl penicillenic acid was measured by the optical absorption at 322 mμ. The pH effects on the antigenic binding of penicillin G to albumin were the same on the conversion rate of penicillin G to benzyl penicillenic acid. Therfore irreversible binding of penicillin G to albumin to make a complete antigen appeared to be mediated by the formation of benzyl penicillenic acid. However most of the sera from patients with anaphylactoid reaction to penicillin, sometime to other drugs, irrespective to reagin to penicillin had strong capacity for antigenic binding without acidification. The mechanism of this type of antigenic binding of penicillin to protein remained to be studied.View full abstractDownload PDF (1380K) -
Masahiro Sato, Aiko FujiwaraArticle type: Article
1963 Volume 12 Issue 3-4 Pages 125-130,136
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSAlthough many reports on the analysis of the functional mechanism of properdin and comments on its clinical and immunological roles have been issued, there has been no agreement among the investigators concerning the fundamental problem of its survey methods. The authors, therefore, examined some methods of properdin survey with zymosan assay and explored the merits and weaknesses of them. They are methods after (1) Pillemer, (2) McNall, (3) Fritzsche, (4) Isliker and Linder, (5) Hunter and Hill, (6) Massen, and (7) Yamamoto. Conclusion: (a) Massen's method may be the best for the preparation of R_3 ; (b) for the preparation of Rp, Massen's, again, especially from the serum of guinea pigs; (c) concerning the survey technique of properdin, Yamamoto's may be the most splendid, when R_3 and Rp are to be prepared as described above ; and (d) our freezing and drying method must be the best for the preservation of these agents.View full abstractDownload PDF (835K) -
Tatsushi Ishizaki, Masaharu Muranaka, Masami Otsuka, Akimasa MiyamotoArticle type: Article
1963 Volume 12 Issue 3-4 Pages 131-133,136
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSResulted from cutaneous injection made trially with the diagnosis solution of Paspat (1/l00 solution) in the healthy person group (202 persons), bronchial asthmatic group (35 persons), and antiallergic disorder group (13 persons), the positive rate of the healthy group was quite low (wheal l% and erythemata 2%), but that of the asthmatic group showed 11% on wheal and 29% on erythemata, that is, Paspat indicated to have a tendency to be easily causable to the positivity in the asthmatic, who had a strong infectious factor. Consequently, in case the positivity of Paspat diagnosis solution has a concern with Paspat treatment, it is surmised as effectiveness in the asthmatic, who gets stronger the infectious factor than the inhalation factor. In conclusion, the author expresses our gratitude to Prof. Yoshio Oshima for his kind guidance and revise.View full abstractDownload PDF (412K) -
Article type: Bibliography
1963 Volume 12 Issue 3-4 Pages 134-136
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (253K) -
Article type: Appendix
1963 Volume 12 Issue 3-4 Pages App5-
Published: March 30, 1963
Released on J-STAGE: February 10, 2017
JOURNAL FREE ACCESSDownload PDF (101K)
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