抄録
The author has made a long term observation on the serum protein and the antibody in rabbits sensitized with Streptococcus Pyogenes. And the following results were obtained. 1). The change of Beta and Gamma globulin in serum was observed three times as the peaks during the sensitization. In the first two peaks they were in parallel with the titers of the specific precipitating antibodies (Boyden titer). In the last peak, the titer against the M-protein fraction was low, while the one against the C-polysaccharide fraction was not. 2). The Coombs antibody titers against the M-protein and C-polysaccharide fractions were increasingly observed or remained the same titer after the second change of peaks in Beta and Gamma globulin. 3). The antibodies or antibody-like substances reacting with homologous normal tissue extract were demonstrated. The author, however, could not necessarilly to confirm the increase of the titer during the experimental period. 4). The Coombs titer in the above reaction was rather low in the case of injuried tissue extract as the antigen than the normal tissue extract, while the Boyden titer remaind to be esentially identical. 5). In the long term observation on prolonged sensitization with Streptococcus, the corneal test were carried out and the positive reactions were observed with M-protein and C-polysaccharide fractions. Especially, the latter fraction revealed strong positive reaction. This fact suggests that the fraction plays a significant role in the immune response by Streptococcal infection or allergy.
