ラットにおける同種皮膚移植に及ぼす Prednisolone, 6-MP 及び glycirrhizin の影響について

抄録

The effect of prednisolone, 6-MP and glycirrhizin on the survival period of skin homografts was studied in Donryu rats which were given the transplantation of the skin of Wisteria rats. The direct and indirect anti-globulin test demonstrated the presence of anti-erythrocyte incomplete antibodies in Donryu rats which received the transplantation of the skin of Wistar rats. These antibodies reacted not only with red cells of Donryu rats but also with those of Wistar rats. Anti-platelet antibodies were also demonstrated in the above mentioned rats by complement fixation test. The survival period of the transplanted Wistar rats' skin in ^<60>Co irradiated Donryu rats was markedly shortened by intravenous injections of splenic cells of Donryu rats which had rejected the homoskingrafts. The administration of prednisolone, 6-MP and glycirrhizin prolonged the survival period of homoskingrafts in Donryu rats. Prednisolone and 6-MP suppressed the production of anti-erythrocyte incomplete antibodies and anti-platelet antibodies in Donryu rats which were given the homotransplantation of the skin of Wistar rats. Glycirrhizin had no effect on the production of anti-erythrocyte and antiplatelet antibodies in the above mentioned Donryu rats. It may be concluded that prednisolone and 6-MP prolong the survival period of homoskingrafts by suppressing the antibody production. However, the prolongation of the survival period of homoskingrafts by the administration of glycirrhizin may not be due to the inhibition of antibody production.