気管支喘息に関する臨床的研究 : 室内塵減感作療法を中心として

抄録

Therapeutic efficiency of hyposensitization in those cases of bronchial asthma in which the house dust was highly suspected on clinical basis to be a causative agent as an allergen was evaluated. Total 194 patients were given repeated hyposensitizing injections with a house dust extract and observed for at least one year. The effect of the hyposensitization was evaluated according to our criteria for the therapeutic efficiency that were made mainly considering a shift in the severity of the disease. The hyposensitization therapy was effective in 106 (54.7%) of the 194 cases observed for more than one year, in 72 (50.0%) of the 144 cases observed for more than two years, and so in 30 (39.5%) of the 76 cases followed up for more than three years. The therapeutic efficiency thus appeared to be lowered as the observation period was extended. Influences of various back ground factors on the therapeutic efficiency were summarized as follows:the patients of a younger age, with a shorter duration of the disease, with either atopic, seasonal or acute type of the disease, and the relatively mild cases responded much better to the hyposensitization therapy than those of an old age, with a longer duration. with either mixed, nonseasonal or chronic type, and the relatively severe cases. As to the frequency of injection with the maintenance dose, the group injected more than once a month showed a better response to the therapy than that injected only once a month. Changes in the skin reactivity to the house duct extract tested before and one year after the beginning of the therapy failed to correlate to the therapeutic efficiency.