A Newly Rearranged 2(3→20)Abeotaxane Diterpene from the Bark of Chinese Yew, Taxus mairei

Abstract

  A newly rearranged 2(3→20)abeotaxane diterpenoid with a unique 6/10/6 skeleton was isolated from the bark of the Chinese yew, Taxus mairei. The structure was established as being 7β,13α-diacetoxy-2α,5α,10β-trihydroxy-9-keto-2(3→20)abeotaxane on the basis of 1-D and 2-D NMR data. The relative stereochemistry was defined from the results of a NOESY experiment. This is the first reported isolation of a rearranged 2(3→20)abeotaxane from Taxus mairei.